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The human kallikrein-related peptidases KLKs comprise 15 members KLK1—15 and are the single largest family of serine proteases. The KLKs are utilized, or proposed, as clinically important biomarkers and therapeutic targets of interest in cancer and neurodegenerative disease. All KLKs appear to be secreted as inactive pro-forms pro-KLKs that are activated extracellularly by specific proteolytic release of their N-terminal pro-peptide. This processing is a key step in the regulation of KLK function.

Much recent work has been devoted to elucidating the potential for activation cascades between members of the KLK family, with physiologically relevant KLK regulatory cascades now described in skin desquamation and semen liquefaction. Despite this expanding knowledge of KLK regulation, details regarding the potential for functional intersection of KLKs with other regulatory proteases are essentially unknown.

To elucidate such interaction potential, we have characterized the ability of proteases associated with thrombostasis to hydrolyze the pro-peptide sequences of the KLK family using a previously described pro-KLK fusion protein system. A subset of positive hydrolysis results were subsequently quantified with proteolytic assays using intact recombinant pro-KLK proteins. Pro-KLK11 and 12 can be activated by a broad-spectrum of thrombostasis proteases, with thrombin exhibiting a high degree of selectivity for pro-KLK The results show that proteases of the thrombostasis family can efficiently activate specific pro-KLKs, demonstrating the potential for important regulatory interactions between these two major protease families.

The 15 kallikrein-related peptidase KLK members KLK1—15 represent the largest cluster of S1 or chymotrypsin-like serine proteases within the human genome Yousef and Diamandis Evidence suggests several other KLKs are differentially regulated in specific types of cancer Clements ; Diamandis et al. Additionally, KLK family members have been shown to be intimately associated with physiological processes of skin desquamation Lundstrom and Egelrud ; Brattsand and Egelrud ; Brattsand et al.

US20110223170A1 – Klk-13 antibody inhibitor for treating dry eye – Google Patents

Net profit in the third quarter ended June 30 jumped to RM Excluding the forex gains, the group’s pre-tax profit for the current quarter rose This was on the back of higher crude palm oil CPO and palm kernel prices, as well as increased output from its estates.

DLC Characters (Release Date N/A) Mako: #KLK_MKO DTR: Here is an extensive doc created by our KLK:IF community; it’s a very lengthy.

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KLK3 or prostate specific antigen PSA is a serine protease, which is an established tumour marker of prostatic adenocarcinoma. PSA is now used widely for the diagnosis and monitoring of patients with prostate cancer. In this study, we examined the molecular mechanism underlying the expression of the PSA gene in breast cancer and breast cancer cell lines. We analysed nine breast tumours categorized on the basis of high- or low-PSA expression in tumour cytosols and four breast cancer cell lines.

No mutations were observed in the coding portion of the gene. A polymorphism was observed in exon 2 from three breast tumours. However, sequencing of the promoter and the enhancer elements of the PSA gene reveals several point mutations. Within a 5.

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before 30 September or such other later date determined by KLK. Pursuant to the terms of the S&P, KLK will be funding the initial /ska This information is provided by RNS The company news service from the.

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Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis

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KLK has not disclosed its recent high-risk dealings in the country to Bursa Malaysia, but, in private correspondence, the company denies knowing of the personal involvement of a PNG Minister in the deal On the day that KLK, Maru and other government officials gathered in Port Moresby to sign the Heads of Agreement, it was reportedly found that the paperwork was not in order, twice.

By the end of the day, the signing was put on hold for a later date. The exact reason why the signing of the Heads of Agreement was postponed remain undisclosed. According to company records the Minister transferred his shares to the Independent Public Business Corporation in January for an undisclosed ‘cash consideration’.

However, no changes were made to the listed Directors of the company, of which there are only two.

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At KLK, we have a workforce of close to 40, people worldwide supporting our various operations and businesses and we believe that our employees are of paramount importance to our business sustainability. Because we know that our Company is only as good as the people who work for it, we continue to put a great deal of emphasis on our human resources. We believe that employees are of paramount importance to our business sustainability; thus we welcome dynamic and committed individuals who share our vision and values to join our existing pool of diverse workforce in creating a positive impact in the community that we operate in.

KLK offers a wide spectrum of career choices and requires various competencies as we have diverse operation activities within the Group. Join us now! A Career With A Reputable Company At KLK, we have a workforce of close to 40, people worldwide supporting our various operations and businesses and we believe that our employees are of paramount importance to our business sustainability. Current Vacancies. Full List.

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Will KLK proceed with the corrupt Sepik oil palm deal?

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